The Research Governance Framework for Health and Social Care was first published in October 2001 by the Department of Health with full compliance being required by 1 April 2004. The Chief Scientist Office (CSO) published the first edition of the Research Governance Framework for Health and Community Care in Scotland in 2001. This was updated to the second edition (2006) to ensure consistency with the Medicines for Human Use (Clinical Trials) Regulations 2004. Knowledge of the framework is essential for all staff involved in clinical research. The Framework defines standards for ethics, science, information, health and safety, finance and a quality research culture and sets out responsibilities for all those who participate in, host, fund, manage and undertake research.