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Bone Clinic

Department of Rheumatology  

Ashgrove House

Aberdeen Royal Infirmary

Information on ProliaŽ (denosumab) ? a treatment for osteoporosis


What is osteoporosis?

Osteoporosis is a long term condition that usually requires treatment.  With osteoporosis there is a higher risk of breaking bones, particularly those in the spine, hip and wrists.  With a ?silent? condition like osteoporosis, it might be easy to forget you have an illness.


Why are my bones weaker?

Our bones are continuously being renewed.  Normally there is a balance of old bone being removed (bone resorption) and new bone being created (bone formation).  In osteoporotic patients this balance is disrupted because bone is broken down faster than it can be rebuilt.


Can fractures be prevented?

As we get older, we have a higher risk of breaking a bone.  Osteoporosis causes your bones to become less strong and more fragile and falling is more common.  Lifestyle changes and keeping active can help prevent falling.  Food supplements, such as calcium and vitamin D, and drug treatments can strengthen bones and can reduce your risk of fracture.



About your treatment with  ProliaŽ

How am I given ProliaŽ ?

ProliaŽ is a quick and simple under-the-skin (subcutaneous) injection given every six months by someone trained in injection techniques.


Why have I been given ProliaŽ?

Your doctor has prescribed ProliaŽ to help reduce your risk fractures.  ProliaŽ is a treatment option mimicking the way the body works to prevent bone loss, helping to make your bones stronger and less likely to break.  You may not see any changes or feel any different in yourself when you are taking it, but ProliaŽ can reduce your risk of fractures.


What if I miss an injection?

If you miss your injection, you should contact your doctor to book a new appointment so that you continue to receive ProliaŽ and help reduce your risk of fractures.


Possible side effects

Like all medicines, ProliaŽ can potentially cause side effects, although not everybody gets them.


Possible side effects: occasionally, skin rash or urinary frequency.  Rarely bowel symptoms.


Very rare side effects: osteonecrosis of the jaw (persistent pain and/or non-healing sores of the jaw) after a dental extraction.


Support programme


ProliaŽ patient support programme (prolong).  Ask your doctor or pharmacist for more details.


Osteoporosis societies

National osteoporosis society (NOS)  www.nos.org.uk

International osteoporosis foundation www.iofbonehealth.org


Further advice from local osteoporosis specialist nurse

Fran Keech

01224 555078